Nico Karssemeijer is professor of Computer-Aided Diagnosis. He studied Physics at Delft University of Technology and graduated at the Radboud University Nijmegen, department of Medical Physics. In 1989 he joined the Department of Radiology of theRadboud University Nijmegen Medical Center, where he formed a research group in computer aided detection (CAD). His professorship is in the Faculty of Science of the Radboud University in the section Intelligent Systems of the Institute for Computing and Information Sciences iCIS. He is Associate Editor of IEEE Transactions on Medical Imaging, and member of the Editorial Boards of Physics in Medicine and Biology and Medical Image Analysis. In 2012 and 2013 he was symposium chair of SPIE Medical Imaging while previously he chaired IWDM98 and IPMI 2007. Nico Karssemeijer was closely involved in the development of the R2 ImageChecker, the most widely used CAD system to date, and is co-founder of Matakina, Ltd. (Wellington, New Zealand), a company that develops technology for quantitative mammography. In 2014, he founded ScreenPoint, a company developing image analysis technology for automated reading of mammograms and digital breast tomosynthesis.